TY - JOUR AU - Guerrero-Porras, Gabriel Rafael AU - Sablón-Carrazana, Marquiza AU - Díaz-García, Alicia M. AU - Rodríguez-Tanty, Chryslaine PY - 2023/01/17 Y2 - 2024/03/28 TI - Gd2O3 nanoparticles grafted to Amylovis®-204, with potential affinity for β-amyloid plaques. Part II JF - Revista Cubana de Química JA - Rev Cub Quim VL - 35 IS - 1 SE - DO - UR - https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/5295 SP - 29-45 AB - <p>For Magnetic Resonance Imaging (MRI) visualization of molecular markers —β-amyloid peptide (βA)— of Alzheimer's disease, the use of contrast agents (CAs) is necessary. In clinical practice, obtaining gadolinium(III) oxide nanoparticles (Gd2O3NPs) as ACs is a very active field of research. In this work, one of the Amylovis® compounds, naphthalene derivatives obtained at CNEURO with high affinity for βA, was conjugated to Gd2O3NPs. The Gd2O3NPs were characterized by FT-IR, TEM, TGA, DLS and ζ-potential. By FT-IR and TEM, respectively, the functionalization with carboxyl groups and the size of the Gd2O3NPs (&lt; 10 nm) were corroborated. Although the amount of Amylovis®-204 conjugated could decrease the colloidal stability of Gd2O3NPs, the values of hydrodynamic diameters (&lt; 200 nm) and longitudinal relaxivity of Gd2O3NPs justify their potential use as AC for the proposed purpose.</p> ER -