Synthesis and Characterization of Nanostructured Materials obtained by the Sol-Gel Method, loaded with Antiepileptic Drugs

Authors

  • Dra. Mayra González-Hurtado Centro de Ingeniería e Investigaciones Químicas CIIQ, La Habana, Cuba; Instituto de Ciencia y Tecnología de los Materiales IMRE, Universidad de La Habana, La Habana
  • Dr. Jacques Rieumont-Briones Facultad de Química, Universidad de La Habana, La Habana
  • Dra. Tessy López-Goerne Universidad Autónoma Metropolitana Unidad Xochimilco
  • Laura M. Castro-González Facultad de Química, Universidad de La Habana, La Habana

Abstract

Epilepsy is a chronic brain disorder characterized by repeated attacks or seizures. Some of the most important  drugs  used  for  this kind of disease are phenytoin and valproic acid, however these drugs have  side effects  to the patient when administered orall y or intravenously. Nowadays a  current trend is  to  supply it to the  patient through controlled release systems. This paper aims to propose an effective method to synthesize nanostructured materials loaded with drugs utilizing  an inert carrier matrix obtained by the sol-gel method with different ratios of alkoxide:water. The  matrices  were characterize  by infrared spectroscopy techniques and  Fourier transform, scanning electron microscopy, adsorption isotherm and X-ray diffraction. It was found that the nanostructured materials can be used for implants because of their high compatibility.

Keywords: nano-structured materials, sol-gel, titanium, antiepileptic.

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Published

2015-10-31

How to Cite

González-Hurtado, D. M., Rieumont-Briones, D. J., López-Goerne, D. T., & Castro-González, L. M. (2015). Synthesis and Characterization of Nanostructured Materials obtained by the Sol-Gel Method, loaded with Antiepileptic Drugs. Revista Cubana De Química, 26(3), 202–214. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/283

Issue

Vol. 26 No. 3 (2014)

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Artículos

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