ENCAPSULACIÓN DEL 4-HIDROXI- 3-METOXIBENZALDEHÍDO EN LIPOSOMAS MODIFICADOS CON 1-O-ALQUILGLICEROLES SINTÉTICOS: ESTUDIO DE SU REACTIVIDAD CON EL RADICAL DPPH

Authors

  • Lic. Leniher Castan-Chibás Facultad de Ingeniería Eléctrica, Universidad de Oriente
  • Dra. C. Grisel del Toro-García Instituto de Farmacia y Alimentos, Universidad de La Habana
  • Dr. C. Adolfo A. Fernández-García Centro de Biofísica Médica y Facultad de Matemática-Computación, Universidad de Oriente
  • M. Sc. Manuel González-Pérez Facultad de Ciencias Naturales, Universidad de Oriente
  • M. Sc. Emilia Ortiz-Beatón Facultad de Ingeniería Eléctrica, Universidad de Oriente
  • Daliana Lobo-Torres Facultad de Ingeniería Eléctrica, Universidad de Oriente

Abstract

A study is presented of the encapsulation of 4-hydroxy-3-methoxybenzaldehyde (vanillin) in liposomes, multilamellar vesicles type, modified with the synthetic 1-O- alkylglycerol decilglicerol (C10), and the reactivity of this system with the radical diphenyl-p–picril hidrazi (DPPH). The liposomes were characterized in terms of encapsulation efficiency, holding capacity of the encapsulated solute and ability to capture free radicals. The results show an adequate encapsulation efficiency (greater than 45 %) and high retention of immobilized vanillin after 7 days of storage, in the range of 95 %. These parameters were not influenced by the lipid composition of the vesicles. The encapsulated aldehyde showed a high reactivity with diphenyl-p-picril hidrazi, compared with decilglicerol unencapsulated and vanillin. The reactivity was dependent of the lipid composition of liposomes, this being greater in vesicles containing decilglicerol and
suggesting that the compound increases the capture of free radicals in the formulations. These results demonstrate the feasibility of liposome-encapsulated vanillin, with good encapsulation efficiency and retention, as well as the applicability of the formulations obtained in the antioxidant therapy.
Keywords: liposomes, vanillin, 1-O- alkylglycerols, free radicals, antioxidantes.

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Published

2015-11-04

How to Cite

Castan-Chibás, L. L., del Toro-García, D. C. G., Fernández-García, D. C. A. A., González-Pérez, M. S. M., Ortiz-Beatón, M. S. E., & Lobo-Torres, D. (2015). ENCAPSULACIÓN DEL 4-HIDROXI- 3-METOXIBENZALDEHÍDO EN LIPOSOMAS MODIFICADOS CON 1-O-ALQUILGLICEROLES SINTÉTICOS: ESTUDIO DE SU REACTIVIDAD CON EL RADICAL DPPH. Revista Cubana De Química, 24(1), 83–90. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/315

Issue

Vol. 24 No. 1 (2012)

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Artículos

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