ZEOLITE MODIFIED WITH NaCl FOR ADSORPTION OF ENT[PtCl4ENT]2- IN MODEL DISSOLUTIONS OF THE CISPLATIN PRODUCTION

Authors

  • Alejandra Bayolo-Soler Faculty of Chemical Engineering, Technological University of Havana José Antonio Echeverría, Havana, Cuba
  • Rachel Lombana-Fraguela Institute of Material Sciences and Technology, University of Havana, Havana, Cuba
  • Ania Cabrera-Díaz Faculty of Chemical Engineering, Technological University of Havana José Antonio Echeverría, Havana, Cuba
  • Mario S. Pomares-Alfonso Institute of Material Sciences and Technology, University of Havana, Havana, Cuba
  • Margarita E. Villanueva-Tagle Chemistry Faculty, University of Havana, Havana, Cuba

Keywords:

Adsorción; citostáticos; ENT[PtCl₄ENT]₂; disoluciones modelo; zeolita natural modificada.

Abstract

This study was aimed at the evaluation of natural zeolite modified with NaCl as adsorbent for Pt(II) extraction from dissolutions of ENT[PtCl4ENT]2- and also at the selection of the experimental conditions in which the maximum adsorption capacity is achieved, modelling cisplatin ENT[PtCl2NH3ENT], one of the most worldwide used drug in anticancer therapy. Study of the adsorption capacity was performed in static operation mode by evaluating the influence of initial concentration and pH dissolution, adsorbent doses, contact time and temperature. The selected conditions were: pH 6, 30 min contact time and 1 g·L-1 adsorbent dose. Adsorption capacity at 25 oC was 67 mg·g-1 and higher for 50 oC and 70 oC. The chemisorption was hypothesized as predominant adsorption mechanism supported by the good fitting of pseudo second order kinetic model of Ho and adsorption increasing with temperature. The process was spontaneous, endothermic and the disorder increased after adsorption. For the first time, the high potentiality of NaCl modified zeolite for solid phase extraction of ENT[PtCl4ENT]2- was demonstrated.

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Published

2025-12-10

How to Cite

Bayolo-Soler, A., Lombana-Fraguela, R., Cabrera-Díaz, A., Pomares-Alfonso, M. S., & Villanueva-Tagle, M. E. (2025). ZEOLITE MODIFIED WITH NaCl FOR ADSORPTION OF ENT[PtCl4ENT]2- IN MODEL DISSOLUTIONS OF THE CISPLATIN PRODUCTION. Revista Cubana De Química, 37(1), 86–92. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/5441

Issue

Vol. 37 No. 1 (2025)

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Artículos

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Copyright (c) 2025 Alejandra Bayolo-Soler, Rachel Lombana-Fraguela, Ania Cabrera-Díaz, Mario S. Pomares-Alfonso, Margarita E. Villanueva-Tagle

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