Micropartículas de carboximetilquitosana/alginato entrecruzadas con calcio como sistema para la liberación prolongada de ketoprofeno
Abstract
En este trabajo se prepararon micropartículas de carboximetil quitosana (CMCS) y alginato (ALG) entrecruzadas con CaCl2 cargadas con ketoprofeno (KETO), en composiciones (CMCS-ALG: 0:1, 1:2 y 1:1) para controlar la liberación de este fármaco poco soluble. Se preparó CMCS con grado de sustitución de 1,09 por alquilación directa de la quitosana con ácido monocloroacético en isopropanol. Las micropartículas cargadas con KETO se obtuvieron mediante secado por aspersión. Se caracterizaron por espectroscopia infrarroja, difracción de rayos X y microscopía electrónica de barrido. Las micropartículas se entrecruzaron con CaCl24 M. La liberación del fármaco se realizó a pH 1,2 y 7,4, siendo mayor a pH 7,4. A este pH, las micropartículas CMCS-ALG 0:1 liberaron casi el 75% de KETO en 20 horas. Las otras formulaciones liberaron aproximadamente el 40% del fármaco. Se concluye que las micropartículas de CMCS-ALG reticuladas con calcio constituyen un sistema prometedor para la liberación prolongada de KETO.
Palabras clave: carboximetil quitosana, ketoprofeno, alginato, micropartículas, liberación prolongada.
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