ALGINATE-LIGNIN AND ALGINATE-SILICA MICROCAPSULES CONTAINING GRAPEFRUIT ESSENTIAL OIL AND THEIR CONTROLLED RELEASE MODELLING

Authors

  • Liliana Mariel-Cáceres Centro de Investigación en Química Orgánica Biológica, Facultad Regional Resistencia, Universidad Tecnológica Nacional (QUIMOBI-FRRE-UTN), Argentina
  • Eliana Paola Dagnino Centro de Investigación en Química Orgánica Biológica, Facultad Regional Resistencia, Universidad Tecnológica Nacional (QUIMOBI-FRRE-UTN), Argentina
  • Ester Chamorro Centro de Investigación en Química Orgánica Biológica, Facultad Regional Resistencia, Universidad Tecnológica Nacional (QUIMOBI-FRRE-UTN), Argentina

Keywords:

encapsulation; alginate; lignin; silica; essential oils.

Abstract

Translator        

 

The encapsulation methodology protects essential oils from external factors (air, light, moisture, and high temperatures), limits its degradation, and allows its slow release. This study aimed at optimizing the encapsulation by ionic gelation of grapefruit essential oil in sodium alginate matrix obtaining a yield of more than 50 % and having an efficiency of more than 90 %. Two new matrices were studied, combining sodium alginate with lignin and silica. These components were obtained from biomass rice husks and showed an efficiency of 99,91 %, a yield of 67,183 % when having 1 % of lignin concentration and an efficiency rate of 97,67 %, and a yield of 52,306 % with 0,8 % of silica. Furthermore, vacuum drying was used and it significantly reduced the size and moisture of the microcapsules. The profiles of controlled release considered in each case were adjusted to Peppas and Korsmeyer’s model for polymeric systems.

Author Biographies

Liliana Mariel-Cáceres , Centro de Investigación en Química Orgánica Biológica, Facultad Regional Resistencia, Universidad Tecnológica Nacional (QUIMOBI-FRRE-UTN), Argentina

Translator        

 

 

Eliana Paola Dagnino, Centro de Investigación en Química Orgánica Biológica, Facultad Regional Resistencia, Universidad Tecnológica Nacional (QUIMOBI-FRRE-UTN), Argentina

Translator        

 

 

Ester Chamorro, Centro de Investigación en Química Orgánica Biológica, Facultad Regional Resistencia, Universidad Tecnológica Nacional (QUIMOBI-FRRE-UTN), Argentina

Translator        

 

 

References

TABAN, A.; SAHARKHIZ, M. J.;

HOOSHMANDI, M. “Insecticidal and repellent

activity of three Satureja species against adult red

flour beetles, Tribolium castaneum (Coleoptera:

Tenebrionidae)” En línea. Acta Ecologica Sinica.

, 37(3), 201-206.

http://dx.doi.org/10.1016/j.chnaes.2017.01.001

RIOS MERA, J. D. et al. “Encapsulation

optimization and pH- and temperature-stability of the

complex coacervation between soy protein isolate and

inulin entrapping fish oil”. LWT. 2019, 116, 108555.

https://doi.org/10.1016/j.lwt.2019.108555

CHE, N.; DEMPERE, L. A.; TONG, Z. “Synthesis

of pH-Responsive Lignin-Based Nanocapsules for

Controlled Release of Hydrophobic Molecules”. ACS

Sustainable Chemistry & Engineering. 2016, 4(10),

-5211.

https://doi.org/10.1021/acssuschemeng.6b01209

LEAL MAZZA, K. et al. “Microencapsulation of

marjoram essential oil as a food additive using sodium alginate and whey protein isolate”. International

Journal of Biological Macromolecules. 2023, 123478.

https://doi.org/10.1016/j.ijbiomac.2023.123478

BENAVIDES, S.; CORTÉS, P.; PARADA, J.;

FRANCO, W. “Development of alginate

microspheres containing thyme essential oil using

ionic gelation”. Food chemistry. 2016, 204, 77-83.

http://dx.doi.org/10.1016/j.foodchem.2016.02.104

ARRIOLA, N. D. et al. “Encapsulation of stevia

rebaudiana Bertoni aqueous crude extracts by ionic

gelation - Effects of alginate blends and gelling

solutions on the polyphenolic profile”. Food

Chemistry. 2019, 275, 123-134.

https://doi.org/10.1016/j.foodchem.2018.09.086

DA SILVA C., A. G. et al. “Anthocyanins from

jussara (Euterpe edulis Martius) extract carried by

calcium alginate beads pre-prepared using ionic

gelation”. Powder Technology. 2019, 345, 283-291.

https://doi.org/10.1016/j.powtec.2019.01.016

POPESCU, L. et al. “The Effect of Aromatic Plant

Extracts Encapsulated in Alginate on the Bioactivity,

Textural Characteristics and Shelf Life of Yogurt”.

Antioxidants. 2023, 12(4), 893.

https://doi.org/10.3390/antiox12040893

ATENCIO, S.; MAESTRO, A.; SANTAMARIA,

E.; GUTIÉRREZ, J. M.; GONZÁLEZ, C.

“Encapsulation of ginger oil in alginate-based shell

materials”. Food Bioscience. 2020, 37, 100714.

https://doi.org/10.1016/j.fbio.2020.100714

BELSCAK CVITANOVIC, A. et al. “Emulsion

templated microencapsulation of dandelion

(Taraxacum officinale L.) polyphenols and β-carotene

by ionotropic gelation of alginate and pectin”. Food

hydrocolloids. 2016, 57, 139.

http://dx.doi.org/10.1016/j.foodhyd.2016.01.020

SAIFULLAH, M.; SHISHIR, M. R. I.;

FERDOWSI, R.; RAHMAN, M. R. T.; VAN

VUONG, Q. “Micro and nanoencapsulation, retention

and controlled release of flavor and aroma

compounds: A critical review”. Trends in Food

Science & Technology. 2019, 86, 230-251.

https://doi.org/10.1016/j.tifs.2019.02.030

CHAN, E. S. “Preparation of Ca-alginate beads

containing high oil content: Influence of process

variables on encapsulation efficiency and bead

properties”. Carbohydrate Polymers. 2011, 84(4),

-1275.

https://doi.org/10.1016/j.carbpol.2011.01.015

LI, M.; JIANG, X.; WANG, D.; XU, Z.; YANG,

M. “In situ reduction of silver nanoparticles in the

lignin-based hydrogel for enhanced antibacterial

application”. Colloids and Surfaces B: Biointerfaces.

, 177, 370-376.

https://doi.org/10.1016/j.colsurfb.2019.02.029

HAN, X.; LIANG, J.; FUKUDA, S.; ZHU, L.;

WANG, S. “Sodium alginate-silica composite

aerogels from rice husk ash for efficient absorption of

organic pollutants. Biomass and Bioenergy” Biomass

and Bioenergy. 2022, 159, 106424.

https://doi.org/10.1016/j.biombioe.2022.106424

VASEK, O. M.; CÁCERES, L. M.;

CHAMORRO, E.; VELASCO, G. A. “Antibacterial

activity of Citrus paradisi essential oil”. Journal of

Natural Products. 2015, 8, 16-26.

http://hdl.handle.net/20.500.12272/941

CÁCERES, L. M.; VELASCO, G. A.;

DAGNINO, E. P.; CHAMORRO, E. R.

“Microencapsulación de Aceite de Pomelo con

Alginato de Sodio por Gelificación y Extrusión

Iónica: Optimización y Modelado de la Reticulación y

Estudio de la Cinética de Liberación Controlada”.

Revista Tecnología y Ciencia. 2020, 39, 41-61.

https://doi.org/10.33414/rtyc.39.41-61.2020

DAGNINO, E. P.; CHAMORRO, E. R.;

ROMANO, S. D.; FELISSIA, F. E.; AREA, M. C.

“Optimization of the acid pretreatment of rice hulls to

obtain fermentable sugars for bioethanol production”.

Industrial Crops and Products. 2013, 42, 363.

https://doi.org/10.1016/j.indcrop.2012.06.019

LEVIĆ, S. et al. “Characterization of sodium

alginate/d-limonene emulsions and respective calcium

alginate/d-limonene beads produced by electrostatic

extrusion”. Food Hydrocolloids. 2015, 45, 111-123.

https://doi.org/10.1016/j.foodhyd.2014.10.001

MONTGOMERY, D. C. Diseño y análisis de

experimentos. 2a Edición. México: Limusa Wiley,

686 p. ISBN: 9681861566.

MAJI, T. K.; BARUAH, I.; DUBE, S.;

HUSSAIN, M. R. “Microencapsulation of

Zanthoxylum limonella oil (ZLO) in glutaraldehyde

crosslinked gelatin for mosquito repellent

application”. Bioresource Technology. 2007, 98(4),

-844.

https://doi.org/10.1016/j.biortech.2006.03.005

TANG, S. et al. “Construction of physically

crosslinked chitosan/sodium alginate/calcium ion

double-network hydrogel and its application to heavy

metal ions removal”. Chemical Engineering Journal.

, 393, 124728,

https://doi.org/10.1016/j.cej.2020.124728

DERDAR, H.; BELBACHIR, M.; HARRANE, A.

“A Green Synthesis of Polylimonene Using

Maghnite-H+, an Exchanged Montmorillonite Clay,

as Eco-Catalyst”. Bulletin of Chemical Reactions Engineering & Catalysis. 2019, 14(1), 69-78.

https://doi.org/10.9767/bcrec.14.1.2692.69-78

VAN HOOGMOED, C. G.; BUSSCHER, H. J.;

DE VOS, P. “Fourier transform infrared spectroscopy

studies of alginate-PLL capsules with varying

compositions”. Journal of Biomedical Materials

Research A. 2003, 67(1),172-178.

https://doi.org/10.1002/jbm.a.10086

UM, H.; KANG, R. H.; KIM, D. “Iron-silicatecoated porous silicon nanoparticles for in situ ROS

self-generation”. Colloids and Surfaces B:

Biointerfaces . 2023, 225 113273.

https://doi.org/10.1016/j.colsurfb.2023.113273

CAREY, F. A. Química Orgánica. 6ª

Edición. México: McGraw-Hill Interamericana, 2014.

p. ISBN: 970-10-5610-8

ONAIZI, S. A. et al. “Crude oil/water

nanoemulsions stabilized by biosurfactant: Stability

and pH-Switchability”. Journal of Petroleum Science

and Engineering. 2021, 198, 108173.

https://doi.org/10.1016/j.petrol.2020.108173

BANERJEE, S. et al. “Influence of process

variables on essential oil microcapsule properties by

carbohydrate polymer-protein blends”. Carbohydrate

Polymers. 2013, 93(2), 691-697.

https://doi.org/10.1016/j.carbpol.2013.01.028

NOPPAKUNDILOGRAT, S.; PIBOON, P.;

GRAISUWAN, W.; NUISIN, R.;

KIATKAMJORNWONG, S. “Encapsulated

eucalyptus oil in ionically cross-linked alginate

microcapsules and its controlled release”.

Carbohydrate Polymers. 2015, 131, 23-33.

https://doi.org/10.1016/j.carbpol.2015.05.054

SOLIMAN, E. A.; EL MOGHAZY, A. Y.;

MOHY EL-DIN, M. S.; MASSOUD, M. A.

“Microencapsulation of Essential Oils within

Alginate: Formulation and in vitro Evaluation of

Antifungal Activity”. Journal of Encapsulation and

Adsorption Sciences. 2013, 3(01), 48-55.

http://dx.doi.org/10.4236/jeas.2013.31006

SHAMSUDIN, M. S. et al. “Performance and

interactions of diclofenac adsorption using

Alginate/Carbon-based Films: Experimental

investigation and statistical physics modelling”.

Chemical Engineering Journal. 2022, 428, 131929.

https://doi.org/10.1016/j.cej.2021.131929

FARRÉS, I. F.; NORTON, I. T. “Formation

kinetics and rheology of alginate fluid gels produced

by in situ calcium release”. Food Hydrocolloids.

, 40, 76-84.

http://dx.doi.org/10.1016/j.foodhyd.2014.02.005

ASHRAF, M. A.; KHAN, A. M.; AHMAD,

M.; SARFRAZ, M. “Effectiveness of silica based

sol-gel microencapsulation method for odorants

and flavors leading to sustainable environment”.

Frontiers in Chemistry. 2015, 3, 42.

https://doi.org/10.3389/fchem.2015.00042

MARTIN, M. J.; LARA VILLOSLADA, F.;

RUIZ, M. A.; MORALES, M. E. “Effect of

unmodified starch on viability of alginateencapsulated Lactobacillus fermentum

CECT5716”. LWT - Food Science and Technology.

, 53(2), 480-486.

https://doi.org/10.1016/j.lwt.2013.03.019

SHIM, J.; LIM, J. M.; SHEA, P. J.; OH, B. T.

“Simultaneous removal of phenol, Cu and Cd from

water with corn cob silica-alginate beads”. Journal

of Hazardous Materials. 2014, 2, 129-136.

https://doi.org/10.1016/j.jhazmat.2014.03.010

SIEPMANN, J.; FAISANT, N.; BENOIT, J. P.

“A New Mathematical Model Quantifying Drug

Release from Bioerodible Microparticles Using

Monte Carlo Simulations”. Pharmaceutical

Research. 2002, 19(12), 1885-1893. ISSN: 1573-

X. https://doi.org/10.1023/A:1021457911533

LOCALI PEREIRA, A. R.; LOPES, N. A.;

MENIS HENRIQUE, M. E. C.; JANZANTTI, N.

S.; NICOLETTI, V. R. “Modulation of volatile

release and antimicrobial properties of pink pepper

essential oil by microencapsulation in single- and

double-layer structured matrices”. International

Journal of Food Microbiology. 2020, 335, 108890.

https://doi.org/10.1016/j.ijfoodmicro.2020.108890

LAI, H. et al. “Fabrication and antibacterial

evaluation of peppermint oil-loaded composite

microcapsules by chitosan-decorated silica

nanoparticles stabilized Pickering emulsion

templating”. International Journal of Biological

Macromolecules. 2021, 183, 2314.

https://doi.org/10.1016/j.ijbiomac.2021.05.198

FERNÁNDEZ, J. A.; SANTOS, R. G.;

ESTÉVEZ, G. F. “Cinética de liberación de

cefalexiana desde un biomaterial compuesto por

HAP-200/POVIAC/CaCO3”. Anales de la Real

Academia Nacional de Farmacia. 2009, 75(3).

https://core.ac.uk/download/pdf/230310909.pdf

PAPADOPOULOU, V.; KOSMIDIS, K.;

VLACHOU, M.; MACHERAS, P. “On the use of

the Weibull function for the discernment of drug

release mechanisms”. International Journal of

Pharmaceutics, 2006. 309(1-2), 44-50.

https://doi.org/10.1016/j.ijpharm.2005.10.044

Published

2025-06-10

How to Cite

Mariel-Cáceres , L., Paola Dagnino, E., & Chamorro, E. (2025). ALGINATE-LIGNIN AND ALGINATE-SILICA MICROCAPSULES CONTAINING GRAPEFRUIT ESSENTIAL OIL AND THEIR CONTROLLED RELEASE MODELLING. Revista Cubana De Química, 37(1), 26–39. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/5411

Issue

Section

Artículos