Parámetros termodinámicos de adsorción de los sistemas carbón activado-clordiazepóxido y carbón activado–diazepam

Authors

  • MSc. Carlos A. Rey-Mafull Instituto de Ciencia y Tecnología de Materiales (IMRE-UH), La Habana
  • PhD. Julio Cesar-Llopiz Instituto de Ciencia y Tecnología de Materiales (IMRE-UH), La Habana
  • PhD. Dachamir Hotza Universidad Federal de Santa Catarina (UFSC), Florianopolis-SC
  • MSc. Raquel García-Gallardo Laboratorio Farmacéutico "Reinaldo Gutiérrez", La Habana
  • Téc. Jaison Rockwood-Sánchez Laboratorio de Bioinorgánica de la Universidad de la Habana, La Habana

Abstract

It is study the thermodynamic parameters of chlordiazepoxide and diazepam drugs adsorbed onto six activated carbons: Norit B, BDH, Merck, Panreac, M1 and M, from simulated gastric fluid at pH 1,2 for 4 h were characterized by FTIR, pHzpc,and adsorption of N2 to 77 K. The results of porosity were interpreted with the Dubinin-Radushkevich’s models and BET’ equation. By UV visible spectra residual drugs were monitored. The results show relationship between: increased of temperature, the characteristics of each adsorbent and the behavior of these drugs in acid solution. The positive values of all the isosteric adsorption enthalpies determined from the slope Van‘t Hoffplot (R2 > 97), indicate the nature endothermic process of adsorption. The ∆G<0 in all cases explained the spontaneous character of the adsorption process and the positive values of ∆S state clearly that the randomness increased at the solid-solution interface during adsorption process.
Key words: activated carbon, adsorption, thermodynamics parameters.

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Published

2016-02-09

How to Cite

Rey-Mafull, M. C. A., Cesar-Llopiz, P. J., Hotza, P. D., García-Gallardo, M. R., & Rockwood-Sánchez, T. J. (2016). Parámetros termodinámicos de adsorción de los sistemas carbón activado-clordiazepóxido y carbón activado–diazepam. Revista Cubana De Química, 25(2), 235–249. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/797

Issue

Vol. 25 No. 2 (2013)

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Artículos

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