Chemical-analytic determination of Carbamazepine in antitoxic service. Presentation of case

Authors

  • Ing. Dayana Marín-Sánchez Centro de Toxicología y Biomedicina, Santiago de Cuba
  • Lic. Liliana Pérez-Jackson Centro de Toxicología y Biomedicina, Santiago de Cuba
  • Lic. Jorge de la Vega-Acosta Centro de Toxicología y Biomedicina, Santiago de Cuba
  • Lic. José C. Rodríguez-Tito Departamento de Ciencias Agropecuarias, Universidad de Oriente, Santiago de Cuba
  • Ing. Neyda Pérez-Garrido Centro de Toxicología y Biomedicina, Santiago de Cuba
  • Ing. Dagmara Ferrer-Salas Centro de Toxicología y Biomedicina, Santiago de Cuba

Abstract

The drugs of narrow therapeutic margin constitutes one of the involuntary main causing chemical agents of exogenous intoxications type, one of the most common is the Carbamazepine.  The clinical case describes a 7 years old male patient, which presented convulsions, hypotension, hypothermia and coma. At the admission moment in the hospital was considered the practice of the toxicological analytic chemical analysis for the causal agent's determination. The determination was  carried out for the method of gas chromatography-mass spectrometry, in acids and basics urine extracts, for the confirmation of the diagnostic hypothesis. The results corroborated Carbamazepine as causal agent of intoxication, corresponding with the signs  and clinical symptoms experienced by the patient. It a treatment with general measures of support was applied being reported a satisfactory clinical evolution.

Keywords: carbamazepine, intoxication, GC-MS.

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Published

2015-10-30

How to Cite

Marín-Sánchez, I. D., Pérez-Jackson, L. L., de la Vega-Acosta, L. J., Rodríguez-Tito, L. J. C., Pérez-Garrido, I. N., & Ferrer-Salas, I. D. (2015). Chemical-analytic determination of Carbamazepine in antitoxic service. Presentation of case. Revista Cubana De Química, 27(3), 302–307. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/247

Issue

Vol. 27 No. 3 (2015)

Section

Artículos

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