Aminación reductiva del 4,5-dimetoxi-9,10-dioxo-9,10-dihidroantraceno-2-carbaldehído derivado de aloe-emodin
Abstract
La aminación reductiva para obtener aminas derivadas del carbaldehído del aloe-emodin 1,8-O-protegido empleando diferentes condiciones y agentes reductores es reportada en este artículo. El aldehído fue obtenido con buen rendimiento usando dióxido de manganeso como agente oxidante. De igual manera, se reporta la síntesis de nuevas iminas derivadas de dicho aldehído con buenos rendimientos. Usando borohidruro de sodio en metanol, como agente reductor para la aminación reductiva, se obtuvieron los mejores resultados y las condiciones fueron ajustadas para incrementar el porciento de conversión hasta un 59 % del producto deseado. Se obtuvieron los mismos resultados partiendo del aldehído o de la imina, usando el procedimiento indirecto o paso a paso, respectivamente.
Palabras clave: aloe-emodin, aminación reductiva, imina, amina, borohidruro de sodio
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