Physicochemical stability of hydroethanolic extract to 70 % of Spondias mombin L. Leaves
Keywords:
spondias mombin L.; anacardiaceae; medicinal plants; stability.Abstract
The aim of the present work was to determine some quality parameters and to evaluate the stability of hydroethanolic to 70% extract of leaves of Spondias mombin L. (Anacardiaceae), stored at room temperature for one year. This specie is used traditionally for the treatment of diverse diseases because to its activity as antibacterial, anti-inflammatory and antioxidant. The leaves were collected in different stages of the cycle of life and it was used the maceration method. High-performance liquid chromatography (HPLC) analysis showed the presence of important phytoconstituents such as gallic acid and derivates and quercetin 3-O- glucosides. The parameters: organoleptic characteristics, pH, relative density, total solids, fixed solids, volatile solids, total phenolic and total flavonoids content were determined; the confidence intervals were established. The obtained data from the extract to the study of stability, related with these parameters, allow to assure stable behaviour during one year, from a physical-chemical standpoint.
References
1. Organización Mundial de la Salud. Estrategia de la OMS sobre medicina tradicional 2014-2023. ISBN 978 92 4 350609 8.
2. LÓPEZ-REGUEIRO, S.; et al. “Fitoterapia como coadyuvante en el tratamiento de la obesidad”, Farmacéuticos Comunitarios. 2012, 4(4), 166-174. ISSN: 2173-9218.
3. GAFNER, S. and BERGUERON, C. “The challenges of chemical stability testing of herbal extract in finished products using State-of-the-Art analytical methodologies”. Current Pharmaceutical Analysis. 2005, 1, 203-215. DOI 10.2174/157341205402.
4. OSUNTOKUN, O. T. “Exploring the Medicinal Efficacy, Properties and Therapeutic uses of Spondias mombin (Linn)”, International Journal of Applied Research on Medicinal Plants. 2019, 2, 115-123. DOI: 10.29011/IJARMP-115.100115.
5. AKOYA, A. O., et al. “Medicinal and economic value of Spondias mombin”, African Journal of Biomedical Research. 2008, 11, 129 - 136. DOI 10.4314/ajbr.v11i2.50714.
6. SAMEH, S.; et al. “Genus Spondias: A Phytochemical and Pharmacological Review”, Evidence-Based Complementary and Alternative Medicine. 2018, Article ID 5382904, 13 pages. https://doi.org/10.1155/2018/5382904.
7. PÉREZ-PORTERO, Y. et al. “Plantas antidermatofíticas, utilizadas en comunidades costeras del municipio Guamá, Santiago de Cuba”, Etnobiología. 2009, 7, 56-62. ISSNe 2448-8151. ISSN 1665-2703.
8. ARAÚJO DA SILVA, A. R. et al. “Chemical composition, antioxidant and antibacterial activities of two Spondias species from North-eastern Brazil”, Pharmaceutical Biology. 2012, 50 (6), 740-746. DOI: 10.3109/13880209.2011. 627347.
9. ALVES-BRITO, S. et al. “Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.” Hindawi Oxidative Medicine and Cellular Longevity, 2018, ID 1731459, 20 pages. https://doi.org/10.1155/2018/1731459.
10. CORTHOUT, J. “Antiviral ellagitannins from Spondias mombin”, Phytochemistry. 1991, 30(4), 1129-1130. https://doi.org/10.1016/S0031-9422(00)95187-2.
11. SILVA, A. R. A., et al. “Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus”, The Journal of Venomous Animals and Toxins including Tropical Diseases. 2011, 17, 406–413. ISSN 1678-9199.
12. FRED-JAIYESIMI, A.; KIO, A. y RICHARD, W. “α-Amylase inhibitory effect of 3b-olean-12-en-3-yl (9Z)-hexadec-9-enoate isolated from Spondias mombin leaf”, Food Chemistry. 2009, 116, 285–288. doi:10.1016/j.foodchem.2009.02.047.
13. CABRAL, B. et al. “Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves”, Revista Brasileira de Farmacognosia. 2016, 26, 304–311. http://dx.doi.org/10.1016/j.bjp.2016.02.002.
14. REY-BLANES, C. et al. “In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves”, Biomedicine & Pharmacotherapy.2020, 131, 110716. https://doi.org/10.1016/j.biopha.2020. 110716.
15. CHUKWUKA, N.; UCHENDU, A. AND ISEK, T. “Antifertility activity of aqueous ethanolic leaf extract of Spondias mombin (Anacardiaceae) in rats”, Health Sciences, 2008, 8(3), 163-167. PMCID: PMC2583269. PMID: 19357744. ISSN 2372-5079
16. NKANU, E. E. “In vivo hypolipidemic and hypoglycemic effects of aqueous extract of Spondias mombin leaves and detoxification of reactive oxygen species in alloxan-induced diabetic rats”, International Journal of Biological Chemistry Science. 2016, 10(4), 1573-1579. ISSNe 1997-342X ISSN 1991-8631.
17. IGWE, C.U. et al. “Evaluation of the Chemical Compositions of the Leaf of Spondias Mombin Linn from Nigeria”, Australian Journal of Basic and Applied Sciences. 2010, 4(5), 706-710. ISSN 1991-8178.
18. PEREIRA, C. et al. “Phytochemical and phylogenetic Analysis of Spondias (Anacardiaceae)”, Química Nova. 2015, 38(6), 813-816. http://dx.doi.org/10.5935/0100-4042.20150087.
19. PROCHÁZKOVÁ, D.; BOUŠOVÁ I.; WILHELMOVÁ, N. “Antioxidant and prooxidant properties of flavonoids”, Fitoterapia. 2011, 82, 513–523. http://doi:10.1016/j.fitote.2011.01.018.
20. A. O. AYOKA, et al. “Sedative, antiepileptic and antipsychotic effects of Spondias mombin L. (Anacardiaceae) in mice and rats”, Journal of Ethnopharmacology. 2006, 103 (2), 166–175. DOI 10.1016/j.jep.2005.07.019.
21. MINSAP. NRSP No. 309. Medicamentos de origen vegetal: droga cruda. Métodos de ensayos. La Habana: MINSAP, 1992. https://cecmed.cu.
22. MINSAP. NRSP No. 311. Medicamentos de origen vegetal: Extractos fluidos y tinturas. Procesos tecnológicos. La Habana: MINSAP, 1992. https://cecmed.cu.
23. HARBORNE J. B. Phytochemical Methods. 3ed. London: Chapman - Hall, 1998. ISBN-13: 978-0-412-23050-9 e-ISBN-13: 978-94-009-5921-7. DOl: 10.1007/978-94-009-5921-7
24. PÉREZ-PORTERO, Y. et al. “Caracterización fitoquímica de extractos de Spondias mombin L. (Anacardiaceae)”, Revista Cubana de Química. 2013, 25(2), 150-153. ISSNe 2224-5421.
25. ENGELS, C. et al. “Characterization of phenolic compounds in jocote (Spondias purpurea L.) peels by ultra-high-performance liquid chromatography/electrospray ionization mass spectrometry”, Food Research International. 2012, 46, 557–562. doi:10.1016/j.foodres.2011.04.003.
26. MINSAP. NRSP No. 312. Métodos de ensayos para la determinación de los requisitos de los extractos fluidos y tinturas. La Habana: MINSAP, 1992. https://cecmed.cu.
27. APHA. Standard Methods for the Examination of Water and Wastewater. 2540 B, 2540E Edition 20. Washington: APHA/AWWA/WEF, 1998. ISBN 0-87553-235-7.
28. SINGLETON, V. L., ORTHOFER, R. y LAMUELA-RAVENTOS, R. M. “Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent”. Methods Enzymology. 1999, 299, 152-78. https://doi.org/10.1016/S0076-6879(99)99017-1.
29. LAKENBRINK, C., et al. “Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages”. Journal of Agricultural and Food Chemistry. 2000, 48, 2848–2852. https://doi.org/10.1021/jf9908042.
30. SIMIC´, A. Z. et al. “Study of ellagic acid electro-oxidation mechanism”. Monatshefte fur Chemie. 144, 121-128, 2013. DOI 10.1007/s00706-012-0856-8.
31. ROMANI, A.; CAMPO, M. and PINELLI, P. “HPLC/DAD/ESI-MS analyses and anti-radical activity of hydrolyzable tannins from different vegetal species”. Food Chemistry. 2012, 130, 214-221. doi: 10.1016/j.foodchem.2011.07.009.
32. DOURADO, R. S. y LADEIRA, A, M. “Identificação de flavonóides em Hypericum cordatum (Vell.) N. Robson (Clusiaceae)”. Brazilian Journal of Botany. 2008, 31(4), 611-620. ISSN 1806-9959. http://dx.doi.org/10.1590/S0100-84042008000400007.
33. AVALOS-GARCÍA, A. y PÉREZ-URRIA CARRIL. “Metabolismo secundario de plantas”. Reduca (Biología). Serie Fisiológica Vegetal. 2009, 2(3), 119-145. ISSN: 189-3620.
34. CRISTOFOLI, N. L. et al. “Antioxidant and antimicrobial potential of cajazeira leaves (Spondias mombin) extracts”. Separation Science and Technology. 2018, 54(4), 1-11 ISSN: 0149-6395 (Print) 1520-5754 (Online). https://doi.org/10.1080/01496395.2018.1508233.
35. MITCHELL, J. D. y DALY D. C. “A revision of Spondias L. (Anacardiaceae) in the Neotropics”. PhytoKeys. 2015, 55, 1–92. doi: 10.3897/phytokeys.55.8489.
36. SOKOLOVÁ, R. et al. “The oxidation of natural flavonoid quercetin”, Chemical Communications. 2012, 48, 3433–3435. DOI: 10.1039/c2cc18018a.
2. LÓPEZ-REGUEIRO, S.; et al. “Fitoterapia como coadyuvante en el tratamiento de la obesidad”, Farmacéuticos Comunitarios. 2012, 4(4), 166-174. ISSN: 2173-9218.
3. GAFNER, S. and BERGUERON, C. “The challenges of chemical stability testing of herbal extract in finished products using State-of-the-Art analytical methodologies”. Current Pharmaceutical Analysis. 2005, 1, 203-215. DOI 10.2174/157341205402.
4. OSUNTOKUN, O. T. “Exploring the Medicinal Efficacy, Properties and Therapeutic uses of Spondias mombin (Linn)”, International Journal of Applied Research on Medicinal Plants. 2019, 2, 115-123. DOI: 10.29011/IJARMP-115.100115.
5. AKOYA, A. O., et al. “Medicinal and economic value of Spondias mombin”, African Journal of Biomedical Research. 2008, 11, 129 - 136. DOI 10.4314/ajbr.v11i2.50714.
6. SAMEH, S.; et al. “Genus Spondias: A Phytochemical and Pharmacological Review”, Evidence-Based Complementary and Alternative Medicine. 2018, Article ID 5382904, 13 pages. https://doi.org/10.1155/2018/5382904.
7. PÉREZ-PORTERO, Y. et al. “Plantas antidermatofíticas, utilizadas en comunidades costeras del municipio Guamá, Santiago de Cuba”, Etnobiología. 2009, 7, 56-62. ISSNe 2448-8151. ISSN 1665-2703.
8. ARAÚJO DA SILVA, A. R. et al. “Chemical composition, antioxidant and antibacterial activities of two Spondias species from North-eastern Brazil”, Pharmaceutical Biology. 2012, 50 (6), 740-746. DOI: 10.3109/13880209.2011. 627347.
9. ALVES-BRITO, S. et al. “Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.” Hindawi Oxidative Medicine and Cellular Longevity, 2018, ID 1731459, 20 pages. https://doi.org/10.1155/2018/1731459.
10. CORTHOUT, J. “Antiviral ellagitannins from Spondias mombin”, Phytochemistry. 1991, 30(4), 1129-1130. https://doi.org/10.1016/S0031-9422(00)95187-2.
11. SILVA, A. R. A., et al. “Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus”, The Journal of Venomous Animals and Toxins including Tropical Diseases. 2011, 17, 406–413. ISSN 1678-9199.
12. FRED-JAIYESIMI, A.; KIO, A. y RICHARD, W. “α-Amylase inhibitory effect of 3b-olean-12-en-3-yl (9Z)-hexadec-9-enoate isolated from Spondias mombin leaf”, Food Chemistry. 2009, 116, 285–288. doi:10.1016/j.foodchem.2009.02.047.
13. CABRAL, B. et al. “Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves”, Revista Brasileira de Farmacognosia. 2016, 26, 304–311. http://dx.doi.org/10.1016/j.bjp.2016.02.002.
14. REY-BLANES, C. et al. “In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves”, Biomedicine & Pharmacotherapy.2020, 131, 110716. https://doi.org/10.1016/j.biopha.2020. 110716.
15. CHUKWUKA, N.; UCHENDU, A. AND ISEK, T. “Antifertility activity of aqueous ethanolic leaf extract of Spondias mombin (Anacardiaceae) in rats”, Health Sciences, 2008, 8(3), 163-167. PMCID: PMC2583269. PMID: 19357744. ISSN 2372-5079
16. NKANU, E. E. “In vivo hypolipidemic and hypoglycemic effects of aqueous extract of Spondias mombin leaves and detoxification of reactive oxygen species in alloxan-induced diabetic rats”, International Journal of Biological Chemistry Science. 2016, 10(4), 1573-1579. ISSNe 1997-342X ISSN 1991-8631.
17. IGWE, C.U. et al. “Evaluation of the Chemical Compositions of the Leaf of Spondias Mombin Linn from Nigeria”, Australian Journal of Basic and Applied Sciences. 2010, 4(5), 706-710. ISSN 1991-8178.
18. PEREIRA, C. et al. “Phytochemical and phylogenetic Analysis of Spondias (Anacardiaceae)”, Química Nova. 2015, 38(6), 813-816. http://dx.doi.org/10.5935/0100-4042.20150087.
19. PROCHÁZKOVÁ, D.; BOUŠOVÁ I.; WILHELMOVÁ, N. “Antioxidant and prooxidant properties of flavonoids”, Fitoterapia. 2011, 82, 513–523. http://doi:10.1016/j.fitote.2011.01.018.
20. A. O. AYOKA, et al. “Sedative, antiepileptic and antipsychotic effects of Spondias mombin L. (Anacardiaceae) in mice and rats”, Journal of Ethnopharmacology. 2006, 103 (2), 166–175. DOI 10.1016/j.jep.2005.07.019.
21. MINSAP. NRSP No. 309. Medicamentos de origen vegetal: droga cruda. Métodos de ensayos. La Habana: MINSAP, 1992. https://cecmed.cu.
22. MINSAP. NRSP No. 311. Medicamentos de origen vegetal: Extractos fluidos y tinturas. Procesos tecnológicos. La Habana: MINSAP, 1992. https://cecmed.cu.
23. HARBORNE J. B. Phytochemical Methods. 3ed. London: Chapman - Hall, 1998. ISBN-13: 978-0-412-23050-9 e-ISBN-13: 978-94-009-5921-7. DOl: 10.1007/978-94-009-5921-7
24. PÉREZ-PORTERO, Y. et al. “Caracterización fitoquímica de extractos de Spondias mombin L. (Anacardiaceae)”, Revista Cubana de Química. 2013, 25(2), 150-153. ISSNe 2224-5421.
25. ENGELS, C. et al. “Characterization of phenolic compounds in jocote (Spondias purpurea L.) peels by ultra-high-performance liquid chromatography/electrospray ionization mass spectrometry”, Food Research International. 2012, 46, 557–562. doi:10.1016/j.foodres.2011.04.003.
26. MINSAP. NRSP No. 312. Métodos de ensayos para la determinación de los requisitos de los extractos fluidos y tinturas. La Habana: MINSAP, 1992. https://cecmed.cu.
27. APHA. Standard Methods for the Examination of Water and Wastewater. 2540 B, 2540E Edition 20. Washington: APHA/AWWA/WEF, 1998. ISBN 0-87553-235-7.
28. SINGLETON, V. L., ORTHOFER, R. y LAMUELA-RAVENTOS, R. M. “Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent”. Methods Enzymology. 1999, 299, 152-78. https://doi.org/10.1016/S0076-6879(99)99017-1.
29. LAKENBRINK, C., et al. “Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages”. Journal of Agricultural and Food Chemistry. 2000, 48, 2848–2852. https://doi.org/10.1021/jf9908042.
30. SIMIC´, A. Z. et al. “Study of ellagic acid electro-oxidation mechanism”. Monatshefte fur Chemie. 144, 121-128, 2013. DOI 10.1007/s00706-012-0856-8.
31. ROMANI, A.; CAMPO, M. and PINELLI, P. “HPLC/DAD/ESI-MS analyses and anti-radical activity of hydrolyzable tannins from different vegetal species”. Food Chemistry. 2012, 130, 214-221. doi: 10.1016/j.foodchem.2011.07.009.
32. DOURADO, R. S. y LADEIRA, A, M. “Identificação de flavonóides em Hypericum cordatum (Vell.) N. Robson (Clusiaceae)”. Brazilian Journal of Botany. 2008, 31(4), 611-620. ISSN 1806-9959. http://dx.doi.org/10.1590/S0100-84042008000400007.
33. AVALOS-GARCÍA, A. y PÉREZ-URRIA CARRIL. “Metabolismo secundario de plantas”. Reduca (Biología). Serie Fisiológica Vegetal. 2009, 2(3), 119-145. ISSN: 189-3620.
34. CRISTOFOLI, N. L. et al. “Antioxidant and antimicrobial potential of cajazeira leaves (Spondias mombin) extracts”. Separation Science and Technology. 2018, 54(4), 1-11 ISSN: 0149-6395 (Print) 1520-5754 (Online). https://doi.org/10.1080/01496395.2018.1508233.
35. MITCHELL, J. D. y DALY D. C. “A revision of Spondias L. (Anacardiaceae) in the Neotropics”. PhytoKeys. 2015, 55, 1–92. doi: 10.3897/phytokeys.55.8489.
36. SOKOLOVÁ, R. et al. “The oxidation of natural flavonoid quercetin”, Chemical Communications. 2012, 48, 3433–3435. DOI: 10.1039/c2cc18018a.
Downloads
Published
2021-10-26
How to Cite
Pérez-Portero, Y., Vera-Ayala, A., García-Díaz, J., Escalona-Arranz, J. C., & Casals-Hung, M. (2021). Physicochemical stability of hydroethanolic extract to 70 % of Spondias mombin L. Leaves. Revista Cubana De Química, 33(3), 305–325. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/5188
Issue
Section
Artículos
License
This journal provides immediate open access to its content, based on the principle that offering the public free access to research helps a greater global exchange of knowledge. Each author is responsible for the content of each of their articles.
