Development of nanostructured polymeric particles system to controlled release of 5-fluorouracil
Keywords:
n-butylcyanoacrylate; 5-Fluorouracil; controlled liberation; polymeric particles.Abstract
This work describes the process of preparation of particles polymeric submicrometric of n-butilo butylcyanoacrylate loaded with 5-Fluorouracil, designed as a liberation system controlled to treat carcinoma in skin, able to improve the therapeutic value of this cytostatic one, overcoming this way the disadvantages of its use in formulations that contain it free. The departure monomer was synthesized and characterized by means of technical spectroscopic. The particles were obtained by means of polymerization in emulsion and they were characterized to FT-GO, RMN-1H, RMN-13C and MALDI-TOF. The particle size, morphology and characteristic electrokinetics were analyzed by means of DLS, SEM and potential zed. Two methodologies were employees to load the particles with the cytostatic one: superficial adsorption and absorption or encapsulation in the main polymeric. The load processes were followed using UV or HPLC. The nanosphere was stable and of smaller diameter at 500nm. The efficiency of encapsulation of the 5Fluorouracil was of 30% for both methodologies.
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