Development of nanostructured polymeric particles system to controlled release of 5-fluorouracil



n-butylcyanoacrylate; 5-Fluorouracil; controlled liberation; polymeric particles.


This work describes the process of preparation of particles polymeric submicrometric of n-butilo butylcyanoacrylate loaded with 5-Fluorouracil, designed as a liberation system controlled to treat carcinoma in skin, able to improve the therapeutic value of this cytostatic one, overcoming this way the disadvantages of its use in formulations that contain it free. The departure monomer was synthesized and characterized by means of technical spectroscopic. The particles were obtained by means of polymerization in emulsion and they were characterized to FT-GO, RMN-1H, RMN-13C and MALDI-TOF. The particle size, morphology and characteristic electrokinetics were analyzed by means of DLS, SEM and potential zed. Two methodologies were employees to load the particles with the cytostatic one: superficial adsorption and absorption or encapsulation in the main polymeric. The load processes were followed using UV or HPLC. The nanosphere was stable and of smaller diameter at 500nm. The efficiency of encapsulation of the 5Fluorouracil was of 30% for both methodologies.


1. WAQAS, R.; SHAIKH, Z.; NAWAS, Y. “Epidemiology and Risk Factors of Basal Cell Carcinoma”. In: MIDGEN, M. R.; CHEN, L.; SILAPUNT S. (Eds.). Basal Cell Carcinoma. Cham: Springer Nature, 2020, pp 1-18. ISBN: 978-3-030-26887-9
2. OLIVEIRA, B., et al. “5-Fluorouracil, innovative drug delivery systems to enhance bioavailability for topical use”, Journal of Drug Delivery Science and Technology. 2020, 61 (102155), 1-11. ISSN: 1773-22473
3. PATEL, G.; DALWADI, C. “Cytotoxicity and Cellular Uptake of 5-Fluorouracil Loaded Methylcellulose Nanohydrogel for Treatment of Oral Cancer", Letters in Applied NanoBioScience. 2021, 10 (1), 1904-1918. ISSN: 2284-6808
4. MATUS-SANTOS, J. A., “Revisión del monitoreo farmacocinético del 5-fluorouracilo como herramienta para incrementar eficacia y seguridad”, Revista Médica del Instituto Mexicano del Seguro Social. 2016, 54 (3), 354-362. ISSN: 0443-5117
5. CALIENNI, M., et al. “Nano-formulation for topical treatment of precancerous lesions: skin penetration, in vitro, and in vivo toxicological evaluation”, Drug Delivery and Translational Research. 2018, 8 (3), 496-514. ISSN: 2190-393X
6. MANSOORI, B., et al. “Hyaluronic acid‐ decorated liposomal nanoparticles for targeted delivery of 5‐ fluorouracil into HT‐ 29 colorectal cancer cells”, Journal of Cellular Physiology. 2020, 235 (10), 6817-6830. ISSN: 0021-9541
7. PELISSARI, F., et al. “Potential of nanoparticles as drug delivery system for cancer treatment”. In: INAMUDDIN, A. M.; ASIRI, A. M. (Eds.). Applications of Nanocomposite Materials in Drug Delivery. Oxford :Woodhead Publishing, 2018, pp 431-468. ISBN: 978-0-12813741-3
8. VAUTHIER, C.; LABARRE, D.; PONCHEL, G. “Design aspects of poly (alkylcyanoacrylate) nanoparticles for drug delivery”, Journal of Drug Targeting. 2007, 15 (10), 641-663. ISSN: 1061-186X
9. ARIAS, J. L., et al. “Study of carbonyl iron/poly (butylcyanoacrylate)(core/shell) particles as anticancer drug delivery systems: Loading and release properties”, European Journal of Pharmaceutical Sciences. 2008, 33 (3), 252-261. ISSN: 0928-0987
10. VAUTHIER, C., et al. “Poly (alkylcyanoacrylates) as biodegradable materials for biomedical applications”, Advanced Drug Delivery Reviews. 2003, 55 (4), 519-548. ISSN: 0169-409X
11. GAO, S., et al. "Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems", Journal of Drug Targeting. 2015, 23 (6), 481-96. ISSN: 1061-186X
12. KATTAN, J., et al. “Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles”, Investigational New Drugs. 1992, 10 (3), 191-199. ISSN: 0167-6997
13. ESTANQUEIRO, M., et al. “Nanotechnological carriers for cancer chemotherapy: the state of the art”, Colloids and surfaces B: Biointerfaces. 2015, 126, 631-48. ISSN: 0927-7765
14. OJHA, B., et al. “Nanotechnology: Introduction and Basic Concepts”. In: KUMAR, N.; JAIN, K. (Eds.). Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives. Boca Raton: CRC Press, 2021, pp.1-19. ISBN: 9778-1-003-02991-5
15. CHENG, H., et al. “Design of self-polymerized insulin loaded poly(n-butylcyanoacrylate) nanoparticles for tunable oral delivery”, Journal of Controlled Release. 2020, 321, 641-653. ISSN: 0168-3659
16. ARIAS, J. L., et al. “Magnetite/poly (alkylcyanoacrylate)(core/shell) nanoparticles as 5Fluorouracil delivery systems for active targeting”, European Journal of Pharmaceutics and Biopharmaceutics. 2008, 69 (1), 54-63. ISSN: 0939-6411
17. AHLIN, P., et al. “Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration”. International Journal of Pharmaceutics. 2002, 239 (1-2), 113-120. ISSN: 03785173
18. BENNET, D.; KIM, S. "Polymer Nanoparticles for Smart Drug Delivery". In: SEZER, A. D. (Eds.). Application of Nanotechnology in Drug Delivery. Rijeka: InTech, 2014, pp. 257-310. ISBN: 978-953-51-5756-4
19. ARIAS J. L., et al. “Poly (alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery: a comparative study”, Colloids and Surfaces B: Biointerfaces. 2008, 62 (1), 64-70. ISSN: 0927-7765
20. ARSALAN, A., et al. “Surface-modified polymeric nanoparticles for drug delivery to cancer cells”, Expert Opinion on Drug Delivery. 2021, 18 (1), 1-24. ISSN: 1742-5247
21. GRAF, A.; McDOWELL, A.; RADES, T. “Poly (alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics–is there real potential?”, Expert Opinion on Drug Delivery. 2009, 6 (4), 371-387. ISSN: 1742-5247



How to Cite

Ferrer-Viñals, D., Álvarez-Brito, R., & Baeza-Fonte, A. N. (2021). Development of nanostructured polymeric particles system to controlled release of 5-fluorouracil. Revista Cubana De Química, 33(2), 113–135. Retrieved from

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