Release study of 5-fluorouracil from poly (butylcyanoacrylate) nanoparticles
Keywords:
5-fluorouracil; controlled release; nanoparticles; poly (butylcyanoacrylate).Abstract
5-Fluorouracil (5-FU) is a cytostatic commonly used in cancer treatment. Today, it seeks to enhance its pharmacological use trying to reduce adverse effects. This research studies the release of 5-FU from an adsorbed and encapsulated poly (butylcyanoacrylate) nanoparticles system for its subsequent use as a controlled release system. The encapsulated particles were obtained by the emulsion polymerization method, in the presence of 5-FU in the medium, while those adsorbed were obtained by contact of the polymeric particles with the 5-FU in solution. The adsorption process could be adequately described by the Langmuir. Preliminary release experiments showed that a zero-order kinetic model is fulfilled for both processes, where the released percentage of encapsulated 5-FU is greater (61,4 %) than that of adsorbed (7,7 %).
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