Estudio de liberación de 5-fluorouracilo desde nanopartículas de policianoacrilato de n-butilo
Palavras-chave:
5-fluorouracilo; liberación controlada; nanopartículas; policianoacrilato de n-butilo.Resumo
El 5-fluorouracilo (5-FU) es un citostático comúnmente empleado en el tratamiento del cáncer. Hoy en día, se busca potenciar su uso farmacológico tratando de reducir los efectos adversos. En esta investigación se estudia la liberación de 5-FU, adsorbido y encapsulado, para su posterior uso como sistema de liberación controlada desde un sistema de nanopartículas de policianoacrilato de n-butilo. Las partículas encapsuladas se obtuvieron por el método de polimerización en emulsión, en presencia de 5-FU en el medio, mientras las adsorbidas lo fueron mediante contacto de las partículas poliméricas con el 5-FU en disolución. El proceso de adsorción pudo ser descrito adecuadamente por los modelos de Langmuir. El porcentaje liberado de 5-FU encapsulado (61,4 %) resultó mayor que el de adsorbido (7,7 %), resultando el primero, más idóneo. Los experimentos preliminares de ambos procesos demostraron que cumplen con un modelo cinético de orden cero.
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