ELECTROSPUN CHITOSAN/POLYVINYL ALCOHOL CEFUROXIME MEMBRANES, WITH POTENTIAL USE AS AN ANTIMICROBIAL DRESSING

Authors

  • Sheyla Bermudez-Pérez Centro de Estudios Avanzados (CEA), La Habana, Cuba
  • Jorge L. Borrego-Díaz Centro de Estudios Avanzados (CEA), La Habana, Cuba
  • Jomarien García-Couce Centro de Biomateriales (BIOMAT), Universidad de La Habana, La Habana, Cuba
  • Ahmed Valdés-Martínez Centro de Estudios Avanzados (CEA), La Habana, Cuba
  • Eduardo Peón-Avés Centro de Biomateriales (BIOMAT), Universidad de La Habana, La Habana, Cuba

Keywords:

electrospinning, chitosan, poly(vinyl alcohol), drug delivery, antibacterial activity

Abstract

Electrospun chitosan and polyvinyl alcohol (QS/PVA) nanofibers have gained noticeability in biomedicine, but their loading with cefuroxime (CFX) had not been previously explored. This work introduces the novel preparation of CFX-loaded QS/PVA nanofibers and evaluates their properties. The membranes exhibited mostly homogeneous nanofibrous structures, as confirmed by Scanning Electron Microscopy (SEM). The micrographs guided the establishment of optimal working conditions, specifically a QS/PVA ratio of 25:75 and a 0,64 mm needle diameter to optimize morphology. Infrared spectroscopy revealed possible interactions between the drug and the matrix, suggesting an affinity between both components. The release study showed an initial rapid burst of the drug followed by a more sustained release over time. In antibacterial tests, the loaded nanofibers showed good inhibitory activity against E. coli. Overall, the CFX-loaded QS/PVA membranes demonstrated high potential as wound dressings.

References

Al Programa Nacional de Nanociencias y Nanotecnologías PN3 y al Proyecto PN211LH008-019 titulado: “Implementación, caracterización y validación de técnicas para la obtención de nanomateriales con aplicaciones en la ingeniería de tejidos y la industria farmacéutica”.

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Published

2026-04-15

How to Cite

Bermudez-Pérez, S., Borrego-Díaz, J. L., García-Couce, J., Valdés-Martínez, A., & Peón-Avés, E. (2026). ELECTROSPUN CHITOSAN/POLYVINYL ALCOHOL CEFUROXIME MEMBRANES, WITH POTENTIAL USE AS AN ANTIMICROBIAL DRESSING. Revista Cubana De Química, 37, 147–156. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/5463

Issue

Vol. 37 (2025)

Section

Artículos

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Copyright (c) 2025 Sheyla Bermudez-Pérez, Jorge L. Borrego-Díaz, Jomarien García-Couce, Ahmed Valdés-Martínez, Eduardo Peón-Avés

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