Nanoparticles of Gd2O3 pegylated and conjugated to amylovis with potential application in the detection of alzheimer by MRI


  • Julio Ricardo Rodríguez-Izquierdo Laboratorio de Bioinorgánica Departamento de Química General e Inorgánica, Facultad de Química, Universidad de La Habana, La Habana, Cuba
  • Armando Augusto Paneque-Quevedo Laboratorio de Bioinorgánica Departamento de Química General e Inorgánica, Facultad de Química, Universidad de La Habana, La Habana, Cuba
  • Marquiza Sablón-Carrazana Departamento de Neuroquímica, Centro de Neurociencias de Cuba
  • Chryslaine Rodríguez-Tanty Departamento de Neuroquímica, Centro de Neurociencias de Cuba
  • Alicia Díaz-García Laboratorio de Bioinorgánica Departamento de Química General e Inorgánica, Facultad de Química, Universidad de La Habana, La Habana, Cuba
  • Evelio González-Dalmau Departamento de Resonancia Magnética, Centro de Neurociencias de Cuba


alzheimer disease; contrast agent; nanoparticles; gadolinium oxide; MRI.


Specific contrast agents facilitate the use of Magnetic Resonance Imaging (MRI) in the early diagnosis of Alzheimer's disease (AD). In the present work, a procedure for the synthesis of a potential MRI contrast agent based on PEGylated Gd2O3 particles is developed for conjugation to Amylovis®, a family of compounds that has shown a high affinity for the pathological structures present in AD. The products obtained were characterized by FT-IR, ICP, TGA, DLS and SEM. Amylovis-functionalized Gd2O3 particles showed a spherical morphology, with an average hydrodynamic diameter of 2.5 μm. These particles presented an adequate value of the ratio between the longitudinal (r1) and transversal (r2) relaxivities (r2/r1 = 2.4). This suggests that once these particles have a hydrodynamic diameter smaller than 200 nm, they could be used as a potential contrast agent for MRI.


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How to Cite

Rodríguez-Izquierdo, J. R., Paneque-Quevedo, A. A., Sablón-Carrazana, M., Rodríguez-Tanty, C., Díaz-García, A., & González-Dalmau, E. (2021). Nanoparticles of Gd2O3 pegylated and conjugated to amylovis with potential application in the detection of alzheimer by MRI. Revista Cubana De Química, 33(2), 3–22. Retrieved from

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