Synthesis and characterization of iron oxide nanoparticles modified with amylovis derivatives
Keywords:Alzheimer disease; magnetic nanoparticles; iron oxide, Amylovis.
Magnetic iron oxide nanoparticles (NPs) have been widely used as contrast agents in magnetic resonance imaging. In recent years, interest has been focused on obtaining and functionalizing them to make them better vectors and more soluble or specific to a given target. In the present work, we report the synthesis and characterization of NPs functionalized with two naphthalene derivatives (Amylovis), which exhibit high affinity for β-amyloid plaques characteristic of Alzheimer's disease (AD). These ones were characterized by FT-IR, TGA, DLS and SEM. The obtained NPs were conjugated by Steglich's method to two different Amylovis molecules, determined this by ligand differences on the surface of the synthesized NPs. Amylovis functionalized NPs could be useful for the detection of amyloid plaques that would contribute to an early diagnosis of AD.
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Copyright (c) 2022 Andy Guzmán-Rodríguez, Armando Augusto Paneque-Quevedo, Marquiza Sablón-Carrazana, Chryslaine Rodríguez-Tanty, Alicia Díaz-García
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