Synthesis and characterization of iron oxide nanoparticles modified with amylovis derivatives

Authors

  • Andy Guzmán-Rodríguez Laboratorio de Bioinorgánica, Departamento de Química General e Inorgánica, Facultad de Química, Universidad de La Habana, La Habana, Cuba
  • Armando Augusto Paneque-Quevedo Laboratorio de Bioinorgánica, Departamento de Química General e Inorgánica, Facultad de Química, Universidad de La Habana, La Habana, Cuba
  • Marquiza Sablón-Carrazana Departamento de Neuroquímica, Centro de Neurociencias de Cuba. La Habana, Cuba
  • Chryslaine Rodríguez-Tanty Departamento de Neuroquímica, Centro de Neurociencias de Cuba. La Habana, Cuba
  • Alicia Díaz-García Laboratorio de Bioinorgánica, Departamento de Química General e Inorgánica, Facultad de Química, Universidad de La Habana, La Habana, Cuba 2Departamento de Neuroquímica, Centro de Neurociencias de

Keywords:

Alzheimer disease; magnetic nanoparticles; iron oxide, Amylovis.

Abstract

Magnetic iron oxide nanoparticles (NPs) have been widely used as contrast agents in magnetic resonance imaging. In recent years, interest has been focused on obtaining and functionalizing them to make them better vectors and more soluble or specific to a given target. In the present work, we report the synthesis and characterization of NPs functionalized with two naphthalene derivatives (Amylovis), which exhibit high affinity for β-amyloid plaques characteristic of Alzheimer's disease (AD). These ones were characterized by FT-IR, TGA, DLS and SEM. The obtained NPs were conjugated by Steglich's method to two different Amylovis molecules, determined this by ligand differences on the surface of the synthesized NPs. Amylovis functionalized NPs could be useful for the detection of amyloid plaques that would contribute to an early diagnosis of AD.

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Published

2022-02-21

How to Cite

Guzmán-Rodríguez, A. ., Paneque-Quevedo, A. A. ., Sablón-Carrazana, M. ., Rodríguez-Tanty, C. ., & Díaz-García, A. . (2022). Synthesis and characterization of iron oxide nanoparticles modified with amylovis derivatives. Revista Cubana De Química, 34(1), 49–68. Retrieved from https://cubanaquimica.uo.edu.cu/index.php/cq/article/view/5208

Issue

Vol. 34 No. 1 (2022)

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Copyright (c) 2022 Andy Guzmán-Rodríguez, Armando Augusto Paneque-Quevedo, Marquiza Sablón-Carrazana, Chryslaine Rodríguez-Tanty, Alicia Díaz-García

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